Myeloid-derived miR-223 regulates intestinal inflammation via repression of the NLRP3 inflammasome.

ABSTRACT: MicroRNA (miRNA)-mediated RNA interference regulates many immune processes, but how miRNA circuits orchestrate aberrant intestinal inflammation during inflammatory bowel disease (IBD) is poorly defined. Here, we report that miR-223 limits intestinal inflammation by constraining the nlrp3 inflammasome. miR-223 was increased in intestinal biopsies from patients with active IBD and in preclinical models of intestinal inflammation. miR-223^-/y mice presented with exacerbated myeloid-driven experimental colitis with heightened clinical, histopathological, and cytokine readouts. Mechanistically, enhanced NLRP3 inflammasome expression with elevated IL-1β was a predominant feature during the initiation of colitis with miR-223 deficiency. Depletion of CCR2⁺ inflammatory

SUBMITTER: Neudecker V 

PROVIDER: S-EPMC5460990 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature