Interleukin 4 promotes the development of ex-Foxp3 Th2 cells during immunity to intestinal helminths.

ABSTRACT: Immunity to intestinal helminth infections requires the rapid activation of T helper 2 cells (Th2 cells). However, simultaneous expansion of CD4⁺Foxp3⁺ regulatory T cells (T reg cells) impedes protective responses, resulting in chronic infections. The ratio between T reg and effector T cells can therefore determine the outcome of infection. The redifferentiation of T reg cells into Th cells has been identified in hyperinflammatory diseases. In this study, we asked whether ex-T reg Th2 cells develop and contribute to type-2 immunity. Using multigene reporter and fate-reporter systems, we demonstrate that a significant proportion of Th2 cells derive from Foxp3⁺ cells after Heligmosomoides polygyrus infection and airway allergy. Ex-Foxp3 Th2 cells exhib

SUBMITTER: Pelly VS 

PROVIDER: S-EPMC5460998 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature