IL-2^high tissue-resident T cells in the human liver: Sentinels for hepatotropic infection.

ABSTRACT: The liver provides a tolerogenic immune niche exploited by several highly prevalent pathogens as well as by primary and metastatic tumors. We have sampled healthy and hepatitis B virus (HBV)-infected human livers to probe for a subset of T cells specialized to overcome local constraints and mediate immunity. We characterize a population of T-bet^loEomes^loBlimp-1^hiHobit^lo T cells found within the intrahepatic but not the circulating memory CD8 T cell pool expressing liver-homing/retention markers (CD69⁺CD103⁺ CXCR6⁺CXCR3⁺). These tissue-resident memory T cells (T_RM) are preferentially expanded in patients with partial immune control of HBV infection and can remain in the liver after the resolut

SUBMITTER: Pallett LJ 

PROVIDER: S-EPMC5461007 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature