Suppression of murine tumour growth through CD8⁺ cytotoxic T lymphocytes via activated DEC-205⁺ dendritic cells by sequential administration of α-galactosylceramide in vivo.

ABSTRACT: Cancer immunity is mediated through the effective priming and activation of tumour-specific class I MHC molecule-restricted CD8⁺ cytotoxic T lymphocytes (CTLs). DEC-205⁺ dendritic cells (DCs) can cross-present the epitope(s) of captured tumour antigens associated with class I MHC molecules alongside co-stimulatory molecules to prime and activate tumour-specific CD8⁺ CTLs. Immunosuppressive tolerogenic DCs with reduced co-stimulatory molecules may be a cause of impaired CTL induction. Hepa1-6-1 cells were established from the mouse hepatoma cell line Hepa1-6; these cells grow continuously after subcutaneous implantation into syngeneic C57BL/6 (B6) mice and do not prime CD8⁺ CTLs. In this study, we show that the growth of ongoing tumours was suppre

SUBMITTER: Kogo H 

PROVIDER: S-EPMC5461099 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature