Modelling the impact of incarceration and prison-based hepatitis C virus (HCV) treatment on HCV transmission among people who inject drugs in Scotland.

ABSTRACT:

Background and aims

People who inject drugs (PWID) experience high incarceration rates, and previous incarceration is associated with elevated hepatitis C virus (HCV) transmission risk. In Scotland, national survey data indicate lower HCV incidence in prison than the community (4.3 versus 7.3 per 100 person-years), but a 2.3-fold elevated transmission risk among recently released (< 6 months) PWID. We evaluated the contribution of incarceration to HCV transmission among PWID and the impact of prison-related prevention interventions, including scaling-up direct-acting antivirals (DAAs) in prison.

Design

Dynamic mathematical modelling of incarceration and HCV transmission, using approximate Bayesian computation for model calibration.

Setting

Scotland, UK.

Participant

SUBMITTER: Stone J 

PROVIDER: S-EPMC5461206 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature