Volatility and change in chronic pain severity predict outcomes of treatment for prescription opioid addiction.

ABSTRACT:

Background and aims

Buprenorphine-naloxone (BUP-NLX) can be used to manage prescription opioid addiction among persons with chronic pain, but post-treatment relapse is common and difficult to predict. This study estimated whether changes in pain over time and pain volatility during BUP-NLX maintenance would predict opioid use during the taper BUP-NLX taper.

Design

Secondary analysis of a multi-site clinical trial for prescription opioid addiction, using data obtained during a 12-week BUP-NLX stabilization and 4-week BUP-NLX taper.

Setting

Community clinics affiliated with a national clinical trials network in 10 US cities.

Participants

Subjects with chronic pain who entered the BUP-NLX taper phase (n = 125) with enrollment occurring from June 2006 to July 2009

SUBMITTER: Worley MJ 

PROVIDER: S-EPMC5461207 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature