Eight weeks of overfeeding alters substrate partitioning without affecting metabolic flexibility in men.

ABSTRACT:

Background/objective

Impairments in metabolic flexibility (MF) and substrate handling are associated with metabolic syndrome. However, it is unknown whether metabolic inflexibility causes insulin resistance. We therefore measured MF and substrate handling before and after 8 weeks of overfeeding in initially healthy adults as a model of the early stages of insulin resistance.

Subjects/methods

Twenty-nine healthy men (27±5 years old; body mass index 25.5±2.3 kg m^-2) were overfed by 40% above baseline energy requirements for 8 weeks and gained 7.6±2.1 kg of weight. Before and after overfeeding, energy expenditure, substrate oxidation and MF were measured in two ways: (a) during 1 day of eucaloric feeding in a whole-room indirect calorimeter and (b) during a two-step

SUBMITTER: Peterson CM 

PROVIDER: S-EPMC5461218 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature