LPS administration increases CD11b⁺ c-Fms⁺ CD14⁺ cell population that possesses osteoclast differentiation potential in mice.

ABSTRACT: Osteoclasts are multinucleated giant cells that originate from a monocyte/macrophage lineage, and are involved in the inflammatory bone destruction accompanied by periodontitis. Recent studies have shown that osteoclast precursors reside not only in the bone marrow, but also in the peripheral blood and spleen, though the precise characteristics of each precursor have not been analyzed. We hypothesized that the number of osteoclast precursors in those tissues may increase under pathological conditions and contribute to osteoclast formation in vivo in a mouse model. To test this hypothesis, we attempted to identify cell populations that possess osteoclast differentiation potential in the bone marrow, spleen, and blood by analyzing macrophage/monocyte-related cell surface markers such as CD11

SUBMITTER: Enomoto T 

PROVIDER: S-EPMC5461244 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature