Protease-Inhibitor Interaction Predictions: Lessons on the Complexity of Protein-Protein Interactions.

ABSTRACT: Protein interactions shape proteome function and thus biology. Identification of protein interactions is a major goal in molecular biology, but biochemical methods, although improving, remain limited in coverage and accuracy. Whereas computational predictions can guide biochemical experiments, low validation rates of predictions remain a major limitation. Here, we investigated computational methods in the prediction of a specific type of interaction, the inhibitory interactions between proteases and their inhibitors. Proteases generate thousands of proteoforms that dynamically shape the functional state of proteomes. Despite the important regulatory role of proteases, knowledge of their inhibitors remains largely incomplete with the vast majority of proteases lacking an annotated inhibitor

SUBMITTER: Fortelny N 

PROVIDER: S-EPMC5461536 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature