Differential expression analysis at the individual level reveals a lncRNA prognostic signature for lung adenocarcinoma.

ABSTRACT:

Background

Deregulations of long non-coding RNAs (lncRNAs) have been implicated in cancer initiation and progression. Current methods can only capture differential expression of lncRNAs at the population level and ignore the heterogeneous expression of lncRNAs in individual patients.

Methods

We propose a method (LncRIndiv) to identify differentially expressed (DE) lncRNAs in individual cancer patients by exploiting the disrupted ordering of expression levels of lncRNAs in each disease sample in comparison with stable normal ordering. LncRIndiv was applied to lncRNA expression profiles of lung adenocarcinoma (LUAD). Based on the expression profile of LUAD individual-level DE lncRNAs, we used a forward selection procedure to identify prognostic signature for stage I-II LUAD pa

SUBMITTER: Peng F 

PROVIDER: S-EPMC5461634 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature