Chronic diazepam administration increases the expression of Lcn2 in the CNS.

ABSTRACT: Benzodiazepines (BZDs), which bind with high affinity to gamma-aminobutyric acid type A receptors (GABA_A-Rs) and potentiate the effects of GABA, are widely prescribed for anxiety, insomnia, epileptic discharge, and as anticonvulsants. The long-term use of BZDs is limited due to adverse effects such as tolerance, dependence, withdrawal effects, and impairments in cognition and learning. Additionally, clinical reports have shown that chronic BZD treatment increases the risk of Alzheimer's disease. Unusual GABA_A-R subunit expression and GABA_A-R phosphorylation are induced by chronic BZD use. However, the gene expression and signaling pathways related to these effects are not completely understood. In this study, we performed a microarray analysis to investigat

SUBMITTER: Furukawa T 

PROVIDER: S-EPMC5461642 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature