Targeting endosomal acidification by chloroquine analogs as a promising strategy for the treatment of emerging viral diseases.

ABSTRACT: Emerging viruses such as HIV, dengue, influenza A, SARS coronavirus, Ebola, and other viruses pose a significant threat to human health. Majority of these viruses are responsible for the outbreaks of pathogenic lethal infections. To date, there are no effective therapeutic strategies available for the prophylaxis and treatment of these infections. Chloroquine analogs have been used for decades as the primary and most successful drugs against malaria. Concomitant with the emergence of chloroquine-resistant Plasmodium strains and a subsequent decrease in the use as antimalarial drugs, other applications of the analogs have been investigated. Since the analogs have interesting biochemical properties, these drugs are found to be effective against a wide variety of viral infections. As a

SUBMITTER: Al-Bari MAA 

PROVIDER: S-EPMC5461643 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature