Microarray expression profiling in the denervated hippocampus identifies long noncoding RNAs functionally involved in neurogenesis.

ABSTRACT:

Background

The denervated hippocampus provides a proper microenvironment for the survival and neuronal differentiation of neural progenitors. While thousands of lncRNAs were identified, only a few lncRNAs that regulate neurogenesis in the hippocampus are reported. The present study aimed to perform microarray expression profiling to identify long noncoding RNAs (lncRNAs) that might participate in the hippocampal neurogenesis, and investigate the potential roles of identified lncRNAs in the hippocampal neurogenesis.

Results

In this study, the profiling suggested that 74 activated and 29 repressed (|log fold-change|>1.5) lncRNAs were differentially expressed between the denervated and the normal hippocampi. Furthermore, differentially expressed lncRNAs associated with neurogen

SUBMITTER: Deng B 

PROVIDER: S-EPMC5461768 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature