Renal Collectrin Protects against Salt-Sensitive Hypertension and Is Downregulated by Angiotensin II.

ABSTRACT: Collectrin, encoded by the Tmem27 gene, is a transmembrane glycoprotein with approximately 50% homology with angiotensin converting enzyme 2, but without a catalytic domain. Collectrin is most abundantly expressed in the kidney proximal tubule and collecting duct epithelia, where it has an important role in amino acid transport. Collectrin is also expressed in endothelial cells throughout the vasculature, where it regulates L-arginine uptake. We previously reported that global deletion of collectrin leads to endothelial dysfunction, augmented salt sensitivity, and hypertension. Here, we performed kidney crosstransplants between wild-type (WT) and collectrin knockout (Tmem27^Y/- ) mice to delineate the specific contribution of renal versus extrarenal collectrin on BP

SUBMITTER: Chu PL 

PROVIDER: S-EPMC5461790 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature