Potassium Sensing by Renal Distal Tubules Requires Kir4.1.

ABSTRACT: The mammalian distal convoluted tubule (DCT) makes an important contribution to potassium homeostasis by modulating NaCl transport. The thiazide-sensitive Na⁺/Cl^- cotransporter (NCC) is activated by low potassium intake and by hypokalemia. Coupled with suppression of aldosterone secretion, activation of NCC helps to retain potassium by increasing electroneutral NaCl reabsorption, therefore reducing Na⁺/K⁺ exchange. Yet the mechanisms by which DCT cells sense plasma potassium concentration and transmit the information to the apical membrane are not clear. Here, we tested the hypothesis that the potassium channel Kir4.1 is the potassium sensor of DCT cells. We generated mice in which Kir4.1 could be deleted in the kidney after the mice are fully de

SUBMITTER: Cuevas CA 

PROVIDER: S-EPMC5461801 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature