Dataset Information
Dicarboxylic acids as pH sensors for hyperpolarized 13C magnetic resonance spectroscopic imaging.
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ABSTRACT:
SUBMITTER: Korenchan DE
PROVIDER: S-EPMC5462110 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Publications
Dicarboxylic acids as pH sensors for hyperpolarized <sup>13</sup>C magnetic resonance spectroscopic imaging.
The Analyst 20170501 9
Imaging tumoral pH may help to characterize aggressiveness, metastasis, and therapeutic response. We report the development of hyperpolarized [2-<sup>13</sup>C,D<sub>10</sub>]diethylmalonic acid, which exhibits a large pH-dependent <sup>13</sup>C chemical shift over the physiological range. We demonstrate that co-polarization with [1-<sup>13</sup>C,D<sub>9</sub>]tert-butanol accurately measures pH via<sup>13</sup>C NMR and magnetic resonance spectroscopic imaging in phantoms. ...[more]