Mitochondrial function of immune cells in septic shock: A prospective observational cohort study.

ABSTRACT:

Background

Reduced cellular ATP synthesis due to impaired mitochondrial function of immune cells may be a factor influencing the immune response in septic shock. We investigate changes in mitochondrial function and bioenergetics of human monocytes and lymphocyte subsets.

Methods

Thirty patients with septic shock were studied at ICU admission, after 24 and 48 hours, and after resolution of shock. Enzymatic activities of citrate synthase and mitochondrial complexes I, IV, and ATP synthase and ATP content of monocytes, T-cells and B-cells and pro-inflammatory (IL-1β and IL-6) and anti-inflammatory (IL-10) cytokine plasma concentrations were compared to samples from 20 healthy volunteers.

Results

Large variations in mitochondrial enzymatic activities of immune cells of se

SUBMITTER: Merz TM 

PROVIDER: S-EPMC5462395 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature