Alamandine reduces leptin expression through the c-Src/p38 MAP kinase pathway in adipose tissue.

ABSTRACT:

Objective

Obesity is associated with an increased risk of diabetes mellitus, hypertension, and renal dysfunction. Angiotensin 1-7 and alamandine are heptameric renin angiotensin system peptide hormones. Further, alamandine levels increase with renal dysfunction. In the cardiovascular system, angiotensin 1-7 and alamandine produce similar improvements and counterbalance angiotensin II in regulating vascular function. We aimed to determine whether the effect of alamandine on leptin expression and secretion in adipocytes was similar to that of angiotensin 1-7.

Approach and results

We studied isolated peri-renal visceral adipose tissue and peri-renal isolated visceral adipocytes from male Wistar rats. Angiotensin II from 0.01 to 10nM had no effect on leptin expression. Angiotens

SUBMITTER: Uchiyama T 

PROVIDER: S-EPMC5462406 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature