Nanoparticle-Programmed Surface for Drug Release and Cell Regulation via Reversible Hybridization Reaction.

ABSTRACT: A surface directly connects the bulk of a material to its surroundings. The ability to dynamically regulate the surface without affecting the bulk of a material holds great potential for new applications. The purpose of this work was to demonstrate that the surface can be dynamically changed using nanoparticles and oligonucleotides (ODNs) in a reversible and reiterative manner. A dual-functional nanogel was synthesized as the model of nanoparticles using miniemulsion polymerization and click chemistry. The nanogel can not only adsorb drugs for sustained drug release but also bind a surface functionalized with complementary ODNs. Importantly, hybridization reaction and ODN degradation can drive reversible and reiterative nanogel binding to the surface for dynamic change, which in principle

SUBMITTER: Jiang P 

PROVIDER: S-EPMC5462454 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature