Cost-effectiveness analysis of typhoid conjugate vaccines in five endemic low- and middle-income settings.

ABSTRACT:

Background

Typhoid fever remains endemic in low- and middle-income countries. Programmatic use of existing vaccines is limited, but upcoming typhoid conjugate vaccines (TCVs) could warrant wider use. We evaluated the cost-effectiveness of five TCV delivery strategies in three urban areas (Delhi and Kolkata, India and Nairobi, Kenya) and two rural settings (Lwak, Kenya and Dong Thap, Vietnam) with varying incidence.

Methods and findings

We evaluated routine infant vaccination with and without catch-up campaigns among older individuals. We used a dynamic model of typhoid transmission to simulate cases, hospitalizations, deaths, disability-adjusted life-years (DALY) lost, treatment and intervention costs. We estimated cost-effectiveness (in terms of cost in international dollar

SUBMITTER: Antillon M 

PROVIDER: S-EPMC5462484 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature