Polygenic Risk for Schizophrenia Influences Cortical Gyrification in 2 Independent General Populations.

ABSTRACT: Schizophrenia is highly heritable, whereas the effect of each genetic variant is very weak. Since clinical heterogeneity and complexity of schizophrenia is high, considerable effort has been made to relate genetic variants to underlying neurobiological aspects of schizophrenia (endophenotypes). Given the polygenic nature of schizophrenia, our goal was to form a measure of additive genetic risk and explore its relationship to cortical morphology. Utilizing the data from a recent genome-wide association study that included nearly 37 000 cases of schizophrenia, we computed a polygenic risk score (PGRS) for each subject in 2 independent and healthy general populations. We then investigated the effect of polygenic risk for schizophrenia on cortical gyrification calculated from 3.0T structural i

SUBMITTER: Liu B 

PROVIDER: S-EPMC5463795 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature