Chemical composition and the potential for proteomic transformation in cancer, hypoxia, and hyperosmotic stress.

ABSTRACT: The changes of protein expression that are monitored in proteomic experiments are a type of biological transformation that also involves changes in chemical composition. Accompanying the myriad molecular-level interactions that underlie any proteomic transformation, there is an overall thermodynamic potential that is sensitive to microenvironmental conditions, including local oxidation and hydration potential. Here, up- and down-expressed proteins identified in 71 comparative proteomics studies were analyzed using the average oxidation state of carbon (Z_C) and water demand per residue ([Formula: see text]), calculated using elemental abundances and stoichiometric reactions to form proteins from basis species. Experimental lowering of oxygen availability (hypoxia) or water

SUBMITTER: Dick JM 

PROVIDER: S-EPMC5463988 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature