The nematode homologue of Mediator complex subunit 28, F28F8.5, is a critical regulator of C. elegans development.

ABSTRACT: The evolutionarily conserved Mediator complex is a critical player in regulating transcription. Comprised of approximately two dozen proteins, the Mediator integrates diverse regulatory signals through direct protein-protein interactions that, in turn, modulate the influence of Mediator on RNA Polymerase II activity. One Mediator subunit, MED28, is known to interact with cytoplasmic structural proteins, providing a potential direct link between cytoplasmic dynamics and the control of gene transcription. Although identified in many animals and plants, MED28 is not present in yeast; no bona fide MED28 has been described previously in Caenorhabditis elegans. Here, we identify bioinformatically F28F8.5, an uncharacterized predicted protein, as the nematode homologue of MED28. As in othe

SUBMITTER: Kostrouchova M 

PROVIDER: S-EPMC5464003 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature