Structural Network Disorganization in Subjects at Clinical High Risk for Psychosis.

ABSTRACT: Previous network studies in chronic schizophrenia patients revealed impaired structural organization of the brain's rich-club members, a set of highly interconnected hub regions that play an important integrative role for global brain communication. Moreover, impaired rich-club connectivity has also been found in unaffected siblings of schizophrenia patients, suggesting that abnormal rich-club connectivity is related to familiar, possibly reflecting genetic, vulnerability for schizophrenia. However, no study has yet investigated whether structural rich-club organization is also impaired in individuals with a clinical risk syndrome for psychosis. Diffusion tensor imaging and probabilistic tractography was used to construct structural whole-brain networks in 24 healthy controls and 24 subjec

SUBMITTER: Schmidt A 

PROVIDER: S-EPMC5464048 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature