Testing the Validity of Taxonic Schizotypy Using Genetic and Environmental Risk Variables.

ABSTRACT:

Background

Meehl regarded schizotypy as a categorial liability for schizophrenia that is the product of genes, environment, and gene-environment interactions. We sought to test whether schizophrenia-related genotypes and environmental risk factors predict membership in classes defined by taxometric analyses of positive (cognitive-perceptual), negative (interpersonal), and disorganized schizotypy.

Methods

Participants (n = 500) completed the Schizotypal Personality Questionnaire (SPQ) and provided information on the following risk factors: cannabis use, pregnancy and obstetric complications, social adjustment, and family history of psychosis. Saliva samples were obtained so that the frequency of single-nucleotide polymorphism (SNP) alleles associated with risk for developing

SUBMITTER: Morton SE 

PROVIDER: S-EPMC5464059 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature