Germline and somatic BAP1 mutations in high-grade rhabdoid meningiomas.

ABSTRACT:

Background

Patients with meningiomas have widely divergent clinical courses. Some entirely recover following surgery alone, while others have relentless tumor recurrences. This clinical conundrum is exemplified by rhabdoid meningiomas, which are designated in the World Health Organization Classification of Tumours as high grade, despite only a subset following an aggressive clinical course. Patient management decisions are further exacerbated by high rates of interobserver variability, biased against missing possibly aggressive tumors. Objective molecular determinants are needed to guide classification and clinical decision making.

Methods

To define genomic aberrations of rhabdoid meningiomas, we performed sequencing of cancer-related genes in 27 meningiomas from 18 patients

SUBMITTER: Shankar GM 

PROVIDER: S-EPMC5464371 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature