Use of cystatin C to inform metformin eligibility among adult veterans with diabetes.

ABSTRACT:

Aims

Recommendations for metformin use are dependent on eGFR category: eGFR >45 ml/min/1.73 m² - "first-line agent"; eGFR 30-44 - "use with caution"; eGFR<30 - "do not use". Misclassification of metformin eligibility by creatinine-based MDRD GFR estimates (eGFRcr) may contribute to its misuse. We investigated the impact of cystatin c estimates of GFR (eGFRcys) on metformin eligibility.

Methods

In a consecutive cohort of 550 Veterans with diabetes, metformin use and eligibility were assessed by eGFR category, using eGFRcr and eGFRcys. Discrepancy in eligibility was defined as cases where eGFRcr and eGFRcys categories (<30, 30-44, 45-60, and >60 ml/min/1.73 m²) differed with an absolute difference in eGFR of >5 ml/min/1.73 m². We modeled predic

SUBMITTER: Tuot DS 

PROVIDER: S-EPMC5464411 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature