Multigene signature for predicting prognosis of patients with 1p19q co-deletion diffuse glioma.

ABSTRACT:

Background

Co-deletion of 1p and 19q marks a diffuse glioma subtype associated with relatively favorable overall survival; however, heterogeneous clinical outcomes are observed within this category.

Methods

We assembled gene expression profiles and sample annotation of 374 glioma patients carrying the 1p/19q co-deletion. We predicted 1p/19q status using gene expression when annotation was missing. A first cohort was randomly split into training (n = 170) and a validation dataset (n = 163). A second validation set consisted of 41 expression profiles. An elastic-net penalized Cox proportional hazards model was applied to build a classifier model through cross-validation within the training dataset.

Results

The selected 35-gene signature was used to identify high-risk an

SUBMITTER: Hu X 

PROVIDER: S-EPMC5464432 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature