Reciprocal Interactions of Leukemic Cells with Bone Marrow Stromal Cells Promote Enrichment of Leukemic Stem Cell Compartments in Response to Curcumin and Daunorubicin
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ABSTRACT:
SUBMITTER: Mohammadi S
PROVIDER: S-EPMC5464507 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
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Reciprocal Interactions of Leukemic Cells with Bone Marrow Stromal Cells Promote Enrichment of Leukemic Stem Cell Compartments in Response to Curcumin and Daunorubicin
Mohammadi Saeed S Nikbakht Mohsen M Sajjadi Seyed Mehdi SM Rad Fariba F Chahardouli Bahram B Sabour Takanlu Javid J Rostami Shahrbano Sh Alimoghaddam Kamran K Ghavamzadeh Ardeshir A Ghaffari Seyed H SH
Asian Pacific journal of cancer prevention : APJCP 20170301 3
A predominant challenge in developing curative leukemia therapy is interactions of leukemic cells with the bone marrow stromal microenvironment. We aimed to investigate the role of stromal cells, such as bone marrow mesenchymal stromal cells (BMSCs) and osteoblasts (OBs), in curcumin (CUR) and daunorubicin (DNR) induced apoptosis of acute myeloid leukemia (AML) cells. We used KG1 and U937 as leukemia cell line models and treated them with CUR and DNR. The cells were then co-cultured with BMSCs o ...[more]
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