Temperature-amplitude coupling for stable biological rhythms at different temperatures.

ABSTRACT: Most biological processes accelerate with temperature, for example cell division. In contrast, the circadian rhythm period is robust to temperature fluctuation, termed temperature compensation. Temperature compensation is peculiar because a system-level property (i.e., the circadian period) is stable under varying temperature while individual components of the system (i.e., biochemical reactions) are usually temperature-sensitive. To understand the mechanism for period stability, we measured the time series of circadian clock transcripts in cultured C6 glioma cells. The amplitudes of Cry1 and Dbp circadian expression increased significantly with temperature. In contrast, other clock transcripts demonstrated no significant change in amplitude. To understand these experimental results, we an

SUBMITTER: Kurosawa G 

PROVIDER: S-EPMC5464531 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature