The artificial sweetener acesulfame potassium affects the gut microbiome and body weight gain in CD-1 mice.

ABSTRACT: Artificial sweeteners have been widely used in the modern diet, and their observed effects on human health have been inconsistent, with both beneficial and adverse outcomes reported. Obesity and type 2 diabetes have dramatically increased in the U.S. and other countries over the last two decades. Numerous studies have indicated an important role of the gut microbiome in body weight control and glucose metabolism and regulation. Interestingly, the artificial sweetener saccharin could alter gut microbiota and induce glucose intolerance, raising questions about the contribution of artificial sweeteners to the global epidemic of obesity and diabetes. Acesulfame-potassium (Ace-K), a FDA-approved artificial sweetener, is commonly used, but its toxicity data reported to date are considered inadeq

SUBMITTER: Bian X 

PROVIDER: S-EPMC5464538 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature