Multiple extracellular vesicle types in peritoneal dialysis effluent are prominent and contain known biomarkers.

ABSTRACT: Peritoneal dialysis inevitability results in activation of inflammatory processes and its efficiency is highly variable between patients. An improved method to isolate biomarkers and study pathophysiological mechanisms in peritoneal dialysis effluent (PDE) is expected to be of much benefit for the development of this treatment approach and help with patient management. Extracellular vesicles (EVs) are released as part of normal cellular processes. Their proteome is expected to reflect both type and health of their cell of origin. Although there is a significant interest in using EVs for "liquid biopsies", little is reported of their presence or composition in plentiful dialysis waste fluids, including peritoneal dialysis effluent (PDE). Here we determined the presence of EVs in PDE and sub

SUBMITTER: Pearson LJ 

PROVIDER: S-EPMC5464591 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature