K_IR channels tune electrical communication in cerebral arteries.

ABSTRACT: The conducted vasomotor response reflects electrical communication in the arterial wall and the distance signals spread is regulated by three factors including resident ion channels. This study defined the role of inward-rectifying K⁺ channels (K_IR) in governing electrical communication along hamster cerebral arteries. Focal KCl application induced a vasoconstriction that conducted robustly, indicative of electrical communication among cells. Inhibiting dominant K⁺ conductances had no attenuating effect, the exception being Ba²⁺ blockade of K_IR. Electrophysiology and Q-PCR analysis of smooth muscle cells revealed a Ba²⁺-sensitive K_IR current comprised of K_IR2.1/2.2 subunits. This current was surprisingl

SUBMITTER: Sancho M 

PROVIDER: S-EPMC5464710 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature