Activity-induced spontaneous spikes in GABAergic neurons suppress seizure discharges: an implication of computational modeling.

ABSTRACT:

Background

Epilepsy, a prevalent neurological disorder, appears self-termination. The endogenous mechanism for seizure self-termination remains to be addressed in order to develop new strategies for epilepsy treatment. We aim to examine the role of activity-induced spontaneous spikes at GABAergic neurons as an endogenous mechanism in the seizure self-termination.

Methods and results

Neuronal spikes were induced by depolarization pulses at cortical GABAergic neurons from temporal lobe epilepsy patients and mice, in which some of these neurons fired activity-induced spontaneous spikes. Neural networks including excitatory and inhibitory neurons were computationally constructed, and their functional properties were based on our studies from whole-cell recordings. With the chang

SUBMITTER: Lu W 

PROVIDER: S-EPMC5464796 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature