Comparison of Prevalence and Types of Mutations in Lung Cancers Among Black and White Populations.

ABSTRACT:

Importance

Lung cancer is the leading cause of cancer death in the United States in all ethnic and racial groups. The overall death rate from lung cancer is higher in black patients than in white patients.

Objective

To compare the prevalence and types of somatic alterations between lung cancers from black patients and white patients. Differences in mutational frequencies could illuminate differences in prognosis and lead to the reduction of outcome disparities by more precisely targeting patients' treatment.

Design, setting, and participants

Tumor specimens were collected from Baptist Cancer Center (Memphis, Tennessee) over the course of 9 years (January 2004-December 2012). Genomic analysis by massively parallel sequencing of 504 cancer genes was performed at Dana-Fa

SUBMITTER: Campbell JD 

PROVIDER: S-EPMC5464986 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature