Storage of neural histamine and histaminergic neurotransmission is VMAT2 dependent in the zebrafish.

ABSTRACT: Monoaminergic neurotransmission is greatly dependent on the function of the vesicular monoamine transporter VMAT2, which is responsible for loading monoamines into secretory vesicles. The role of VMAT2 in histaminergic neurotransmission is poorly understood. We studied the structure and function of the histaminergic system in larval zebrafish following inhibition of VMAT2 function by reserpine. We found that reserpine treatment greatly reduced histamine immunoreactivity in neurons and an almost total disappearance of histamine-containing nerve fibers in the dorsal telencephalon and habenula, the most densely innervated targets of the hypothalamic histamine neurons. The reserpine treated larvae had an impaired histamine-dependent dark-induced flash response seen during the first second afte

SUBMITTER: Puttonen HAJ 

PROVIDER: S-EPMC5465064 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature