Distinct Blood and Visceral Adipose Tissue Regulatory T Cell and Innate Lymphocyte Profiles Characterize Obesity and Colorectal Cancer.

ABSTRACT: Visceral adipose tissue (VAT) is a main site where metabolic and immunologic processes interplay to regulate, at local and systemic level, the inflammatory status and immune response. Obesity-associated inflammation and immune dysfunctions are inextricably linked to tumor but, in spite of intense efforts, the mechanisms underpinning this association remain elusive. In this report, we characterized the profile of VAT-associated and circulating innate lymphocyte and regulatory T (T_reg) cell subsets underlying inflammatory conditions, such as obesity and colorectal cancer (CRC). Analysis of NK, NKT-like, γδ T, and T_reg cell populations in VAT and blood of healthy lean subjects revealed that CD56^hi NK and OX40⁺ T_reg cells are more abundant

SUBMITTER: Donninelli G 

PROVIDER: S-EPMC5465245 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature