[⁶⁸Ga]/[¹⁸⁸Re] Complexed [CDTMP] Trans-1,2-Cyclohexyldinitrilotetraphosphonic Acid As a Theranostic Agent for Skeletal Metastases.

ABSTRACT:

Objective

Metastasis of the osseous tissue is one of the frequent and severe aggravations as a result of several neoplastic conditions, such as metabolic disorders, infections, and cancer. The objective of this study was to evaluate the pertinence of [⁶⁸Ga]-trans-1,2-cyclohexyldinitrilo tetramethylene phosphonic acid (CDTMP) as a potential bone imaging agent for positron emission tomography (PET) applications as well as to assess [¹⁸⁸Re]-CDTMP for bone pain palliation in metastatic skeletal disorders.

Methods

⁶⁸Ga complex of CDTMP was prepared at 80°C at pH 3.5, and ¹⁸⁸Re complex of CDTMP was prepared at room temperature. [⁶⁸Ga]-CDTMP complex was investigated as PET tracer while the therapeutic efficacy was assessed for

SUBMITTER: Jaswal AP 

PROVIDER: S-EPMC5465288 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature