Testosterone Treatment and Coronary Artery Plaque Volume in Older Men With Low Testosterone.

ABSTRACT:

Importance

Recent studies have yielded conflicting results as to whether testosterone treatment increases cardiovascular risk.

Objective

To test the hypothesis that testosterone treatment of older men with low testosterone slows progression of noncalcified coronary artery plaque volume.

Design, setting, and participants

Double-blinded, placebo-controlled trial at 9 academic medical centers in the United States. The participants were 170 of 788 men aged 65 years or older with an average of 2 serum testosterone levels lower than 275 ng/dL (82 men assigned to placebo, 88 to testosterone) and symptoms suggestive of hypogonadism who were enrolled in the Testosterone Trials between June 24, 2010, and June 9, 2014.

Intervention

Testosterone gel, with the dose adjusted

SUBMITTER: Budoff MJ 

PROVIDER: S-EPMC5465430 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature