Computational prediction of lncRNA-mRNA interactionsby integrating tissue specificity in human transcriptome.

ABSTRACT: Long noncoding RNAs (lncRNAs) play a key role in normal tissue differentiation and cancer development through their tissue-specific expression in the human transcriptome. Recent investigations of macromolecular interactions have shown that tissue-specific lncRNAs form base-pairing interactions with various mRNAs associated with tissue-differentiation, suggesting that tissue specificity is an important factor controlling human lncRNA-mRNA interactions.Here, we report investigations of the tissue specificities of lncRNAs and mRNAs by using RNA-seq data across various human tissues as well as computational predictions of tissue-specific lncRNA-mRNA interactions inferred by integrating the tissue specificity of lncRNAs and mRNAs into our comprehensive prediction of human lncRNA-RNA interaction

SUBMITTER: Iwakiri J 

PROVIDER: S-EPMC5465533 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature