Multifunctional mixed-metal nanoscale coordination polymers for triple-modality imaging-guided photodynamic therapy.

ABSTRACT: The one-step self-assembly preparation of multifunctional gadolinium (Gd)-ytterbium (Yb) mixed-metal nanoscale coordination polymers (NCPs) with Ru[4,4'-(COOH)₂bpy]₃²⁺ (L_Ru , bpy = bipyridyl) as a ligand is reported. The Gd/Yb ratio in the NCPs is easily tuned by their ratio in the precursors while the self-limiting growth is realized with the high coordination valence and rigid steric structure of the precursors. The inherent properties of the precursors, including the magnetic resonance (MR) response of Gd³⁺, the X-ray attenuation properties of Yb³⁺, and the red fluorescence and the singlet-oxygen generation of L_Ru , are well retained in the mixed-metal NCPs. In vivo fluorescence-MR-X-ray co

SUBMITTER: Wang YM 

PROVIDER: S-EPMC5465558 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature