Brain-coX: investigating and visualising gene co-expression in seven human brain transcriptomic datasets.

ABSTRACT:

Background

The pathogenesis of neurological and mental health disorders often involves multiple genes, complex interactions, as well as brain- and development-specific biological mechanisms. These characteristics make identification of disease genes for such disorders challenging, as conventional prioritisation tools are not specifically tailored to deal with the complexity of the human brain. Thus, we developed a novel web-application-brain-coX-that offers gene prioritisation with accompanying visualisations based on seven gene expression datasets in the post-mortem human brain, the largest such resource ever assembled.

Results

We tested whether our tool can correctly prioritise known genes from 37 brain-specific KEGG pathways and 17 psychiatric conditions. We achieved aver

SUBMITTER: Freytag S 

PROVIDER: S-EPMC5465565 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature