Methodological Rigor in Preclinical Cardiovascular Studies: Targets to Enhance Reproducibility and Promote Research Translation.

ABSTRACT:

Rationale

Methodological sources of bias and suboptimal reporting contribute to irreproducibility in preclinical science and may negatively affect research translation. Randomization, blinding, sample size estimation, and considering sex as a biological variable are deemed crucial study design elements to maximize the quality and predictive value of preclinical experiments.

Objective

To examine the prevalence and temporal patterns of recommended study design element implementation in preclinical cardiovascular research.

Methods and results

All articles published over a 10-year period in 5 leading cardiovascular journals were reviewed. Reports of in vivo experiments in nonhuman mammals describing pathophysiology, genetics, or therapeutic interventions relevant to speci

SUBMITTER: Ramirez FD 

PROVIDER: S-EPMC5466021 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature