A systematic review and meta-analysis of genetic association studies for the role of inflammation and the immune system in diabetic nephropathy.

ABSTRACT: Background: Despite the certain contribution of metabolic and haemodynamic factors in diabetic nephropathy (DN), many lines of evidence highlight the role of immunologic and inflammatory mechanisms. To elucidate the contribution of the immune system in the development of DN, we explored the contribution of gene variants (polymorphisms) in relevant pathophysiologic pathways. Methods: We selected six major pathways related to immune response from the Kyoto Encyclopaedia of Genes and Genomes database and thereafter we traced all available genetic association studies (GASs) involving gene variants in these pathways from PubMed and HuGE Navigator. Finally, we used meta-analytic methods for synthesizing the results of the GASs. Results: One hundred three GASs were retrieved

SUBMITTER: Tziastoudi M 

PROVIDER: S-EPMC5466089 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature