Haplotype-based interaction of the PPARGC1A and UCP1 genes is associated with impaired fasting glucose or type 2 diabetes mellitus.

ABSTRACT: The aim of this study is to evaluate the effect of single-nucleotide polymorphisms (SNPs) of the PPARGC1A and UCP1 genes on impaired fasting glucose (IFG) or type 2 diabetes mellitus (T2DM) and the haplotype-based interaction between these genes.A cross-sectional study was conducted by cluster sampling in Henan province, China. Based on the level of fasting plasma glucose (FPG) and the history of T2DM, the participants were divided into 2 groups; 83 individuals were in the IFG+DM group (those with IFG or T2DM) and 445 individuals were in the NFPG group (those with normal FPG). Kernel canonical correlation analysis (KCCA), a haplotype-based gene-gene interaction method, which can increase the biological interpretability and extract nonlinear characteristics of SNPs, was used to analyze the

SUBMITTER: Pei X 

PROVIDER: S-EPMC5466206 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature