Family History and Stroke Risk in China: Evidence from a Large Cohort Study.

ABSTRACT:

Background and purpose

Large cohort studies on relationship between family history of stroke (FHS) and stroke risk are lacking in Asians. We aimed to systematically evaluate the association of FHS with stroke risk in a cohort study of 0.5 million Chinese adults.

Methods

Information about FHS was self-reported. The median follow-up time was 7.16 years and the end-point of follow-up was incident stroke, which was entered directly into the China Kadoorie Biobank system. Multivariate analyses were performed with Cox proportional hazards model, and interaction analyses were carried using likelihood-ratio tests.

Results

Compared with participants without FHS, the hazard ratio (HR) (95% confidence interval, CI) of stroke for participants with FHS was 1.50 (1.46-1.55). The HR

SUBMITTER: Tian T 

PROVIDER: S-EPMC5466298 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature