Lymphatic endothelial progenitors originate from plastic myeloid cells activated by toll-like receptor-4.

ABSTRACT:

Background

Myeloid-derived lymphatic endothelial cells (M-LECP) are induced by inflammation and play an important role in adult lymphangiogenesis. However, the mechanisms driving M-LECP differentiation are currently unclear. We previously showed that activation of Toll-like receptor-4 (TLR4) induces myeloid-lymphatic transition (MLT) of immortalized mouse myeloid cells. Here the goals were to assess the potential of different TLR4 ligands to induce pro-lymphatic reprogramming in human and mouse primary myeloid cells and to identify transcriptional changes regulating this process.

Methodology/principal findings

Human and mouse myeloid cells were reprogrammed to the lymphatic phenotype by TLR4 ligands including lipopolysaccharide (LPS), recombinant high mobility group box 1 pr

SUBMITTER: Volk-Draper LD 

PROVIDER: S-EPMC5466303 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature