Computational analysis of multimorbidity between asthma, eczema and rhinitis.

ABSTRACT:

Background

The mechanisms explaining the co-existence of asthma, eczema and rhinitis (allergic multimorbidity) are largely unknown. We investigated the mechanisms underlying multimorbidity between three main allergic diseases at a molecular level by identifying the proteins and cellular processes that are common to them.

Methods

An in silico study based on computational analysis of the topology of the protein interaction network was performed in order to characterize the molecular mechanisms of multimorbidity of asthma, eczema and rhinitis. As a first step, proteins associated to either disease were identified using data mining approaches, and their overlap was calculated. Secondly, a functional interaction network was built, allowing to identify cellular pathways involved i

SUBMITTER: Aguilar D 

PROVIDER: S-EPMC5466323 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature