Physiology of midbrain head movement neurons in cervical dystonia.

ABSTRACT:

Background

Early theories for cervical dystonia, as promoted by Hassler, emphasized the role of the midbrain interstitial nucleus of Cajal. Focus then shifted to the basal ganglia, and it was further supported with the success of deep brain stimulation. Contemporary theories suggested the role of the cerebellum, but even more recent hypotheses renewed interest in the midbrain. Although the pretectum was visited on several occasions, we still do not know about the physiology of midbrain neurons in cervical dystonia.

Methods

We analyzed the unique database of pretectal neurons collected in the 1970s and 1980s during historic stereotactic surgeries aimed to treat cervical dystonia. This database is valuable because such recordings could otherwise never be obtained from humans.<

SUBMITTER: Sedov A 

PROVIDER: S-EPMC5466497 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature