Adiponectin modulates oxidative stress-induced mitophagy and protects C2C12 myoblasts against apoptosis.

ABSTRACT: Adiponectin (APN), also known as apM1, Acrp30, GBP28 and adipoQ, is a circulating hormone that is predominantly produced by adipose tissue. Many pharmacological studies have demonstrated that this protein possesses potent anti-diabetic, anti-atherogenic and anti-inflammatory properties. Although several studies have demonstrated the antioxidative activity of this protein, the regulatory mechanisms have not yet been defined in skeletal muscles. The aim of the present study was to examine the cytoprotective effects of APN against damage induced by oxidative stress in mouse-derived C2C12 myoblasts. APN attenuated H₂O₂-induced growth inhibition and exhibited scavenging activity against intracellular reactive oxygen species that were induced by H₂O₂.

SUBMITTER: Ren Y 

PROVIDER: S-EPMC5466641 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature